Throughout and within this disclosure are technical and patent publications, referenced by an identifying citation or by an Arabic number. The full bibliographic citation corresponding to the Arabic number is found in the specification, preceding the claims. The disclosures of all references cited herein are incorporated by reference into the present application to more fully describe the state of the art to which this disclosure pertains.
A wide variety of diseases implicate improper immune function in pathogenesis or exacerbation of symptoms. While a wide variety of immunotherapies exist, they are often coupled with off target effects due to lack of targeting specificity and/or adverse side effects.
Thus a need exists with respect to finding safe and effective therapies for these disorders. This disclosure satisfies this need and provides related advantages as well.